Article Side

Online Article Directory!

Hello Guest! Login or Register to submit articles!

Biologic Characteristics of Acute and Chronic Wounds

By Alice Merry Subscribe to RSS | December 26th 2011 | Views:

It was always understood that understanding the basic mechanism of wound healing is very important to treat a wound. In recent times advances in understanding the basic mechanism of wound healing have brought to the forefront optimal treatments of chronic wounds.

If you talk to a professional they will let you know that the exuded fluid from a wound bed is not inert. This fluid has biologic and chemical properties that may either hasten or prolong the healing of a wound.

There has been limited success to find the cause of a specific wound when research trials that included topical administration of specific growth factors, like platelet derived growth factor, pressure, venous, and diabetic wounds were combined with optimal treatment.

Date from experiments suggests that growth factors are multifunctional. These growth factors either facilitate or impede wound healing. This depends on two things, the wound bed matrix and cellular conditions.

Exudates from an acute wound have a lot of growth factors. These specifically include platelet derived growth factor, fibroblast growth factor, and epithelial growth factor. These help promote the proliferation of fibroblasts, keratinocytes, and endothelial cells. This is in case of both in-vitro and in-vivo studies.

There are finite organized inflammatory stages for proteolytic and fibrinolytic agents so as to break down debris in an acute wound.

Concentration of these is decreased subsequently so as to set up the proliferation and re-epithelialization of cells.

Also enzymes called endogenous proteolytic and fibrinolytic break-down the components of the wound bed. The resultant which is produced acts as chemotactic messengers. This attracts more inflammatory cells which hasten the re-epithelialization process.

On the other hand exudate from a chronic wound has different composition from an acute wound. Studies show that this exudate shows decreased cellular mitogenic activity in the chronic wound bed.

It is possible that this characteristic of the exudates could be associated with higher concentrations of matrix metalloprotease proenzymes. Metalloprotease proenzymes help in degrading the wound matrix necessary for optimal healing.

There is usually a competing and prolonged stage of inflammation in a chronic wound. This stage inhibits a nascent proliferative stage.

In conclusion we can then say that the key to healing a chronic wound is that we not only balance moisture levels present in the wound bed but also need to sequester compounds in chronic wound exudate as these could prove to be a barrier to normal healing.

A moisture balanced wound environment is provided by using and applying properly the newer generation wound dressings.

Alice Merry - About Author:
Looking for high quality, reliable and affordable wound care or wound dressings? Look no further! Our top quality products are simply perfect for everyone.

Share on Facebook Tweet It Stumbleupon this post This post is delicious !

Article Source:

Related Health Articles Subscribe to RSS

Anxiety can be a chronic disorder
Published by Book_mydoctor on May 14th 2012 | Health
Stress, fear, nervousness, worry and anxiety are the common feeling among people these days. Such fe...
The air around results in chronic heart complications
Published by Carsonmrtn08 on June 23rd 2012 | Health
Air pollution is not only a risk factor for humans but also causes serious atmospheric effects as we...
Skin care specialist- the best person to help get flawless and beautiful skin
Published by Louise Carala on August 25th 2012 | Health
Skin care specialist in Houston is well skilled to treat patients with even the worst skin disease t...
Various options for the treatment of bronchititis
Published by Justin Bieber on August 25th 2012 | Health
Bronchitis is a problem of the chest in which the walls of the bronchial tubes get inflamed. This pr...
Essentials of eye care
Published by Justin Bieber on August 25th 2012 | Health
All our body parts need care for their normal functioning. In the same way our eyes also need care a...
Probiotic Supplements - How to Choose the Best
Published by Marvin Ferris on August 25th 2012 | Health
The leading probiotic supplements are going to provide you with all of the right ingredients. You sh...
Teeth Whitening Manchester - Procedures for Effective Solution
Published by Julia Roger on August 25th 2012 | Health
Coming to the home remedies recommended by Teeth Whitening Liverpool service providers, using orange...
Spiritual Coaching- Get Enlightened with the Help of a Spiritual Coach
Published by Julia Roger on August 25th 2012 | Health
The main motto of spiritual coaching is to tune a person into the spiritual expedition. A spiritual ...