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Chemical Analysis: Better Quality Control for Pharmaceutical Products

By George Melcher Subscribe to RSS | June 27th 2012 | Views:
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In the manufacturing industry, particularly in pharmaceutical products, chemical analysis is a vital component. It determines the quality and quantity of the elements in every sample. In this way, the manufacturer is assured that there are no deficiencies and the product is ready to be released.

However, chemical analysis is a painstaking job requiring much time and effort, especially if done without the aid of modern equipment or system. It may require additional manpower to train and expensive technology to use. It can lengthen the process of manufacture and availability of the product to consumers.

Pharmaceutical products particularly need to be measured for content uniformity of dosage and identification of raw materials. They must also meet the standards for blend uniformity, drying and coating, granulation, and particle size. This is part of the FDA and European Union health guidelines which need strict compliance before the product can be released to the market.

Manufacturers, however, now have various tools at their disposal to make the process more convenient and precise. There are devices which can be used to rapidly evaluate different pharmaceutical formulations, be they liquid or solid materials. The process can be done with near infrared (NIR) methods at faster and safer rates which can be cost effective too.

There are several applications in the pharmaceutical industry that can use near infrared applications. They include those which are part of government health guidelines like blend uniformity, as discussed earlier. A near infrared system is not only used for analysis, but for research and development of products as well.

NIR applications can actually be implemented in various fields. The tobacco industry, for example, use near infrared analyzers to determine nicotine and menthol content. The wood products industry also uses the same for moisture analysis and adhesive content analysis. It can also analyze moisture in soaps. NIR analyzers come in different models to suit various product analysis needs.

Meanwhile, pharmaceutical manufacturers can use an XDS Masterlab optical design which can operate in a near infrared reflectance mode or transmission mode. They provide rapid and reliable test methods covering various solid dosage forms—layered, coated or cored tablets, capsules, caplets, geltabs, and gelcaps. The reflectance mode analyzes the outside layers, while the transmission mode provides whole body measurement of the dosage form. NIR can provide all the analytical requirements of the pharmaceutical industry to maintain the highest standards of production. If you have further interest on the topic, you may visit ehow.com/how-does_5316121_chemical-analysis-procedures.html.

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